The asialoglycoprotein receptor (ASGPR) is a C-type II lectin located primarily on hepatocytes. ASGPR removes a broad range of desialylated glycoproteins from the bloodstream by binding selectively to terminal galactose (Gal) and <i>N</i>-acetylgalactosamine (GalNAc) residues presented in a multivalent fashion on the termini of glycans located on glycoproteins. The high specificity and selectivity of ASGPR for Gal and GalNAc has inspired the development of several classes of Gal and GalNAc-based carriers for delivering therapeutics to hepatocytes. In this poster, we present the synthesis and evaluation of two new classes of compounds designed to mimic natural desialylated glycans. Our preliminary results demonstrate that these compounds have the potential to selectively engage ASGPR and may be useful for delivering targeted therapeutics to hepatocytes.<br/>

New tools for targeting the asialoglycoprotein receptor

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.