Influenza is a contagious respiratory virus that is responsible for millions of infections and thousands of deaths globally each year. The influenza virus infects host cells by binding to cell surface sialic acid using a hemagglutinin spike protein (HA). After infection and replication, the virus is released from the host cell with the help of a second protein, neuraminidase (NA). Our interest in developing new inhibitors for HA and NA led us to consider the feasibility of using a thermal shift assay for the rapid evaluation of inhibitor candidates. In this poster we present our preliminary results on the development of a thermal shift assay for evaluating HA and NA, including challenges and opportunities for the use of this technique as a rapid screening tool.

Development of a thermal shift assay for evaluating inhibitor candidates targeting viral hemagglutinin and neuraminidase

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.