Peptide nanostructures (PNs) are ubiquitous in Nature. In the past years, synthetic PNs have been extensively studied in the biomaterials field, as they mimic the fibrous part of the ECM morphology formed by proteins such as collagen and support the survival and growth of cells when applied as coatings or 3D matrices. We have identified short peptide sequences that assemble into so-called amyloid structures. Depending on their sequences, interactions with virions and cell membranes have been demonstrated that allowed efficient gene transduction into various cells such as stem cells. These fibrils were coated by a very thin polydopamine layer and the attachment and pH-controlled release of various functionalities as well as stimulated neuronal cell growth was demonstrated. Furthermore, controlled fibril formation in a soft polymer matrix afforded PN cross-linked hydrogels featuring fast gelation, excellent recovery from high strain conditions over multiple cycles, and re-formation after injection as well as macroscopic cutting. These hybrid hydrogels were highly compatible with a number of different cell types, such as endothelial cells or neuronal cells. Therefore, in combination with the opportunity to conveniently introduce new functions, these material offers great potential as a regenerative scaffold for biomedicine.

Peptide-polymer nanostructures and hydrogels to control cellular growth

2019 Spring National Meeting

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