The unique physicochemical and optical properties of gold nanoparticles (Au NPs), together with their excellent biocompatibility recommend these nanomaterials as a versatile platform technology for delivery of drugs and nucleic acids.<br/>We will present our recent results towards the design of ligands that can modulate the surface charge of gold nanoparticles without altering their colloidal stability and thus allow them to act as nucleic acid delivery systems. Alternatively, the design of Au NPs ligands against epitopes expressed on cells in pathological states, as well as Au NPs ligand-drug conjugates can transform Au NPs into targeted drug delivery systems for cancer treatment. The talk will present ligand design details, optimization of AuNPs surface decoration for enhanced colloidal stability, targeting, drug loading and controlled release of cargo. Relevant biological data supporting each application will also be presented.

Functionalization of gold nanoparticles for generation of drug and nucleic acid delivery nanoplatforms

2019 Spring National Meeting

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