2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Biomolecular Technologies

Designing fatty acid-conjugated therapeutic proteins with a high molecular weight for the extended serum half-life

Expansion of genetically encoded amino acids containing a tetrazine functional group for fast protein conjugation

Rapid detection of monoclonal antibodies and other biomolecules through functionalized nanoparticle crosslinking

Using synthetic biology strategies for studying flux towards isobutanol in Saccharomyces cerevisiae

Structure-guided development of a biocatalyst for late-stage halogenation

Designing vaccines that elicit broadly neutralizing antibodies

Discovery of general amyloid inhibitors against the aggregation and toxicity of both amyloid-β and hIAPP

Developing a branched-chain amino acid biosensor from bacterial periplasmic binding proteins for human diagnostics

Visualization and modulation of EF-G power stroke in ribosomal translocation

Mechanically controlled thermodynamics of biorecognition events

Artificial duel-functional enzyme constructed by combining an enzyme and an organometallic catalyst

Deamidation compromises antibody colloidal stability and solubility in a pH-dependent manner

Cost-effective construction of high quality diversity-containing sequences of variable length for protein libraries

Improving protein crystallization outcomes using surface energy modified substrates

Micro-channel cantilever spotting (µCS) and the immobilization of Cucurbit[7]uril complex for determination of sensitivity on analyte exposure

Yeast as a model to study biased signaling of GPCRs

Improved expression of human tachykinin NK2 receptor using a receptor-receptor chimera with the rat homologue

Start with the end in sight: Developability & improved biopharmaceutical molecule quality

Design of membrane-active peptides that assemble into macromolecular-size pores

ROSETTA-informed design of structurally stabilized cyclic anti-amyloid peptides

Engineering a blue light inducible spycatcher system (BLISS) as a tool for protein photopattering and optogenetics

Synthetic molecular evolution of antimicrobial peptides

Characterization of chemically defined media variation on the level of secreted phospholipase-B like protein by recombinant CHO cell cultures

Engineering hyperthermostable rcSso7d as a reporter molecule for in vitro diagnostic tests

Virus detection via osmolyte-induced aggregation of gold nanoparticles

Kinetics and characterization of non-enzymatic fragmentation of monoclonal antibody therapeutics

Development and application of a continuous evolution system to program protein-protein interactions

Screening yeast display libraries against magnetized yeast cell targets enables efficient isolation of membrane protein binders

Engineered bispecific antibodies for targeted inhibition of cancer metastasis

Structural elucidation of engineered tissue inhibitor of metalloproteinase-1 (TIMP-1) variants with improved binding affinity toward matrix metalloproteinase-3 (MMP-3)

High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening: A case study on HBcAg VLP surface charge

Receptor heterodimerization modulates endocytic uptake through both collaborative and competitive mechanisms

Liposome-coated iron oxide nanoparticles (LIONs): A dynamic approach for the investigation of influenza fusion mechanisms

N and C terminal oriented protein conjugation onto nanoparticles using split intein technology

Improving antifungal efficacy for the high mannose binding lectin Myxovirin

Physicochemical determinants of drug-like monoclonal antibodies

Structure-guided discovery of dual-recognition chemibodies

Impact of mobile phase conditions on multimodal ligand association on SAM surfaces

Redirected CAR T activity via CD19-ligand fusions engineered by deep mutational scanning

TNF-α and sophorolipids: Combination approach for the treatment of prostate cancer

Scalable cell-free extract preparation and minimal genetic template methods for rapid protein prototyping

Site-specific fatty acid-conjugation of therapeutic proteins for the extended serum half-life

Single particle virus isoelectric point determination with chemical force microscopy

Conformation and mechanism of ferritin early-step disassembly process at low pH

Engineering quality and manufacturability of a trivalent protein subunit vaccine

Chemometrics approach in establishing functional comparability of biosimilars

Application of kinetic reaction modeling for process development of antibody-drug conjugates

Rapid mapping of glycoprotein structure-activity relationships by glycomutagenesis

Developability assessment of an IgG2 Monoclonal Antibody prior to commencement of process development

Characterization and development of a halogenase enzyme as a tool for synthesis

Polymerization and synthesis of biostyrene by engineering E. coli using iCREATE strategy

Effect of a long genetic fusion tag on the structure and stability of a pharmaceutical protein

Novel LPS trap in cancer immunotherapy

Regulation of trafficking and transport of antibodies across the human blood-brain barrier

Competition study between wild type cyanobacteria Synechococcus elongatus PCC 7942 and plasmid transformant Synechocystis PCC 6803

Triple helix involved in genomic targeting

Immobilization of enzyme fusions on superparamagnetic nanoparticles: Two case studies.

Expression of TALEs in plants and development of TALE arrays for diagnostic applications.

Magnetic relaxation nanosensors (MRnS) for rapid detection and one-step differentiation between subtypes of influenza

Engineered zinc finger proteins immobilized on the silane polymer surface for diagnostic probes to  detect antibiotic resistance genes

Determining ligand binding characteristics of adenosine receptors by fluorescence anisotropy and SPR

Structure and dynamics of the thyroid hormone-activating and deactivating iodothyronine deiodinases

Characterization of the activity of glucuronyl C5-epimerase

Development of deoxyribozyme DNA nanomachines for diagnostics and therapy

Developing and characterizing peptide bacteriocins as antimicrobial therapeutics

Engineering the local environment for enhanced enzyme biocatalysis

Simple preparation of decursin from angelica gigas and its evaluation of alcoholic fatty liver prevention

Effect of homodimer IgG4 bispecific antibody aggregates on controlled Fab-Arm-Exchange (cFAE)

Assessing the stability and expression of transgenes in genetically engineered cyanobacteria for biofuel production

Minimally disruptive optical control of protein tyrosine phosphatases

Directed evolution of high affinity MDM2-binding ligands using stabilized bacterial peptide display

Generation of functional monoclonal antibodies inhibiting matrix metalloproteinases

Pilot purification of horse hemoglobin a1c

Engineering cellular-based selections for translatable ligand discovery

Zinc finger proteins for pathogen detection

Harnessing self-assembly to promote immune tolerance during autoimmune disease

Intra-lymph node delivery of tolerogenic microparticles reverses disease and prevents relapse in a relapsing-remitting model of multiple sclerosis

Chemical testing in a two-organ human-on-a-chip NAFLD model

Improved methods for high-throughput screening of antibody colloidal interactions

Co-ordinated enzyme catalysis: Designing a cell-free system

Conjugation of cofactors using polymeric swing arms enables creation of cofactorless ping pong enzymes with predictable kinetics

Developing a double-stranded DNA biosensor using engineered zinc finger proteins linked to a β-lactamase for detecting antibiotic resistance genes

Accelerating proton transport in a novel biological p-n junction for fabricating an artificial retina

Single cell PK/PD of antibody-drug conjugates: Computational predictions and experimental validation to improve in vivo efficacy of targeted therapeutics

Cell-based selections aid yeast-display discovery of genuine cell-binding ligands: Targeting oncology vascular biomarker CD276

Directed evolution of antibodies with high conformational specificity for glucagon amyloid fibrils

Synthesis of nucleoside analogs for inhibition of HIV-1 RT

Design and evaluation of novel antibody libraries with drug-like specificity

Transient expression of an anthrax decoy protein in Nicotiana benthamiana: The impacts of N-glycosylation on protein expression, stability and function

Engineering stable anaerobic consortia by understanding the genomic basis for syntrophic interactions

Positive selection screens for DNA endonuclease activity

Process development for production of a live biotherapeutic drug product for the treatment of Phenylketonuria

Optimizing key amino acids in CHO cell culture medium improves productivity and reduces waste byproducts for biologics manufacturing

Computational optimization of a thioesterase for selective chain-length product distribution

Biomolecular Technologies

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Designing fatty acid-conjugated therapeutic proteins with a high molecular weight for the extended serum half-life