2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Biomolecular Technologies

Competition study between wild type cyanobacteria Synechococcus elongatus PCC 7942 and plasmid transformant Synechocystis PCC 6803

Engineering the local environment for enhanced enzyme biocatalysis

Developing and characterizing peptide bacteriocins as antimicrobial therapeutics

Development of deoxyribozyme DNA nanomachines for diagnostics and therapy

Characterization of the activity of glucuronyl C5-epimerase

Structure and dynamics of the thyroid hormone-activating and deactivating iodothyronine deiodinases

Determining ligand binding characteristics of adenosine receptors by fluorescence anisotropy and SPR

Engineered zinc finger proteins immobilized on the silane polymer surface for diagnostic probes to  detect antibiotic resistance genes

Magnetic relaxation nanosensors (MRnS) for rapid detection and one-step differentiation between subtypes of influenza

Expression of TALEs in plants and development of TALE arrays for diagnostic applications.

Immobilization of enzyme fusions on superparamagnetic nanoparticles: Two case studies.

Triple helix involved in genomic targeting

Simple preparation of decursin from angelica gigas and its evaluation of alcoholic fatty liver prevention

Regulation of trafficking and transport of antibodies across the human blood-brain barrier

Novel LPS trap in cancer immunotherapy

Effect of a long genetic fusion tag on the structure and stability of a pharmaceutical protein

Polymerization and synthesis of biostyrene by engineering E. coli using iCREATE strategy

Characterization and development of a halogenase enzyme as a tool for synthesis

Developability assessment of an IgG2 Monoclonal Antibody prior to commencement of process development

Rapid mapping of glycoprotein structure-activity relationships by glycomutagenesis

Designing fatty acid-conjugated therapeutic proteins with a high molecular weight for the extended serum half-life

Chemometrics approach in establishing functional comparability of biosimilars

Engineering quality and manufacturability of a trivalent protein subunit vaccine

Chemical testing in a two-organ human-on-a-chip NAFLD model

Design and evaluation of novel antibody libraries with drug-like specificity

Synthesis of nucleoside analogs for inhibition of HIV-1 RT

Directed evolution of antibodies with high conformational specificity for glucagon amyloid fibrils

Cell-based selections aid yeast-display discovery of genuine cell-binding ligands: Targeting oncology vascular biomarker CD276

Single cell PK/PD of antibody-drug conjugates: Computational predictions and experimental validation to improve in vivo efficacy of targeted therapeutics

Accelerating proton transport in a novel biological p-n junction for fabricating an artificial retina

Developing a double-stranded DNA biosensor using engineered zinc finger proteins linked to a β-lactamase for detecting antibiotic resistance genes

Conjugation of cofactors using polymeric swing arms enables creation of cofactorless ping pong enzymes with predictable kinetics

Co-ordinated enzyme catalysis: Designing a cell-free system

Improved methods for high-throughput screening of antibody colloidal interactions

Application of kinetic reaction modeling for process development of antibody-drug conjugates

Intra-lymph node delivery of tolerogenic microparticles reverses disease and prevents relapse in a relapsing-remitting model of multiple sclerosis

Harnessing self-assembly to promote immune tolerance during autoimmune disease

Zinc finger proteins for pathogen detection

Engineering cellular-based selections for translatable ligand discovery

Pilot purification of horse hemoglobin a1c

Generation of functional monoclonal antibodies inhibiting matrix metalloproteinases

Directed evolution of high affinity MDM2-binding ligands using stabilized bacterial peptide display

Minimally disruptive optical control of protein tyrosine phosphatases

Assessing the stability and expression of transgenes in genetically engineered cyanobacteria for biofuel production

Effect of homodimer IgG4 bispecific antibody aggregates on controlled Fab-Arm-Exchange (cFAE)

Cost-effective construction of high quality diversity-containing sequences of variable length for protein libraries

Engineering hyperthermostable rcSso7d as a reporter molecule for in vitro diagnostic tests

Characterization of chemically defined media variation on the level of secreted phospholipase-B like protein by recombinant CHO cell cultures

Synthetic molecular evolution of antimicrobial peptides

Engineering a blue light inducible spycatcher system (BLISS) as a tool for protein photopattering and optogenetics

ROSETTA-informed design of structurally stabilized cyclic anti-amyloid peptides

Design of membrane-active peptides that assemble into macromolecular-size pores

Start with the end in sight: Developability & improved biopharmaceutical molecule quality

Improved expression of human tachykinin NK2 receptor using a receptor-receptor chimera with the rat homologue

Yeast as a model to study biased signaling of GPCRs

Micro-channel cantilever spotting (µCS) and the immobilization of Cucurbit[7]uril complex for determination of sensitivity on analyte exposure

Improving protein crystallization outcomes using surface energy modified substrates

Virus detection via osmolyte-induced aggregation of gold nanoparticles

Deamidation compromises antibody colloidal stability and solubility in a pH-dependent manner

Artificial duel-functional enzyme constructed by combining an enzyme and an organometallic catalyst

Mechanically controlled thermodynamics of biorecognition events

Visualization and modulation of EF-G power stroke in ribosomal translocation

Developing a branched-chain amino acid biosensor from bacterial periplasmic binding proteins for human diagnostics

Discovery of general amyloid inhibitors against the aggregation and toxicity of both amyloid-β and hIAPP

Designing vaccines that elicit broadly neutralizing antibodies

Structure-guided development of a biocatalyst for late-stage halogenation

Using synthetic biology strategies for studying flux towards isobutanol in Saccharomyces cerevisiae

Rapid detection of monoclonal antibodies and other biomolecules through functionalized nanoparticle crosslinking

Expansion of genetically encoded amino acids containing a tetrazine functional group for fast protein conjugation

Receptor heterodimerization modulates endocytic uptake through both collaborative and competitive mechanisms

Redirected CAR T activity via CD19-ligand fusions engineered by deep mutational scanning

TNF-α and sophorolipids: Combination approach for the treatment of prostate cancer

Impact of mobile phase conditions on multimodal ligand association on SAM surfaces

Structure-guided discovery of dual-recognition chemibodies

Physicochemical determinants of drug-like monoclonal antibodies

Improving antifungal efficacy for the high mannose binding lectin Myxovirin

N and C terminal oriented protein conjugation onto nanoparticles using split intein technology

Conformation and mechanism of ferritin early-step disassembly process at low pH

Liposome-coated iron oxide nanoparticles (LIONs): A dynamic approach for the investigation of influenza fusion mechanisms

High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening: A case study on HBcAg VLP surface charge

Scalable cell-free extract preparation and minimal genetic template methods for rapid protein prototyping

Structural elucidation of engineered tissue inhibitor of metalloproteinase-1 (TIMP-1) variants with improved binding affinity toward matrix metalloproteinase-3 (MMP-3)

Engineered bispecific antibodies for targeted inhibition of cancer metastasis

Screening yeast display libraries against magnetized yeast cell targets enables efficient isolation of membrane protein binders

Development and application of a continuous evolution system to program protein-protein interactions

Site-specific fatty acid-conjugation of therapeutic proteins for the extended serum half-life

Kinetics and characterization of non-enzymatic fragmentation of monoclonal antibody therapeutics

Single particle virus isoelectric point determination with chemical force microscopy

Positive selection screens for DNA endonuclease activity

Engineering stable anaerobic consortia by understanding the genomic basis for syntrophic interactions

Computational optimization of a thioesterase for selective chain-length product distribution

Transient expression of an anthrax decoy protein in Nicotiana benthamiana: The impacts of N-glycosylation on protein expression, stability and function

Process development for production of a live biotherapeutic drug product for the treatment of Phenylketonuria

Optimizing key amino acids in CHO cell culture medium improves productivity and reduces waste byproducts for biologics manufacturing

Biomolecular Technologies

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Competition study between wild type cyanobacteria <i>Synechococcus elongatus</i> PCC 7942 and plasmid transformant <i>Synechocystis </i>PCC 6803