Currently used plastics are mostly produced from petrochemical products. However, there is a growing demand for bio-based plastics, which are produced from renewable resources, to establish a more sustainable society and to solve global environmental and waste management problems. All fossil and bio-based polymers contain defects – branches, chain ends and inclusion of functional groups – which are randomly distributed along the polymer chain. This makes difficult to estimate their influence on properties and behavior of the polymer. Acyclic diene metathesis (ADMET) polymerization is a unique strategy for achieving polymers with precise control over the primary structure. We present polyethylene-like, degradable amphiphilic polymer, which was polymerized for the first time by metathesis polymerization. Polymer with molecular weight Mn ca. 13,000 g/mol with precisely spaced vitamin C groups in a polyethylene backbone was obtained, properties and degradability of synthesized product were investigated. Cytotoxicity test, and the cellular uptake measurement of the cyanine dyed polymer shows, that vitamin C containing polymer is biocompatible. These properties make this polymer promising material for biomedicine as drug delivery system protecting cargo from possible free radical damage.

Biobased degradable PE-like polymers with precisely spaced vitamin C groups by acyclic diene metathesis polymerization

2019 Fall National Meeting

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