SUBMISSION

Observation of conformational transition of perfluorophenyl substituted benzanilide derivative

Ryu Yamasaki

Misuzu Harada

Rino Nagata

Ai Ito

Kazuo Fukuda

Iwao Okamoto

0 views
0 downloads

Presented at
2019 Fall National Meeting

Abstract

Acid-induced conformational switching system composed with acetanilide derivatives was first reported in 2003 (Yamasaki, R et al.). However, this system was not operative for benzanilide derivative. To make this switching system work in a benzanilide derivative, we replaced phenyl group with perfluorophenyl group which interact with phenyl group. A replacement of perfluorobenzoyl group found to make N-methylbenzanilide derivatives sensitive to substituents on the anilino group. Finally, N-[p-(dimethylamino)phenyl]-N-phenylbenzanilide changed its stable conformation by adding acid, and the conformational transition was observed by NMR, due to the higher rotational barrier of perfluorobenzoyl substituted benzanilide derivative.

Discussion

Ask a Question

Get involved to find out more about this Presentation.

All Comments

Log In to participate in the discussion

Powered byMorressier logo black

Discover more research and events on morressier.com