Potential safety hazards associated with Pd-catalyzed cross-coupling reactions have been a growing concern in the chemistry community. This presentation will discuss the exothermic behaviors associated with Pd-catalyzed Sonogashira, a-arylation, Suzuki-Miyaura, and Mizoroki-Heck cross-couplings. Thermal stability of certain reaction mixtures will also be presented. In many cases, measured exotherms posed potential safety hazards that may result in a runaway reaction as the maximum temperature of a synthesis reaction (MTSR) exceeded the boiling point of the solvent and/or the onset temperature of the reaction mixture decomposition. Researchers are encouraged to conduct safety evaluations and develop control strategies accordingly to mitigate such potential safety risks prior to practicing similar chemistry.

Potential safety hazards associated with the Pd-catalyzed cross-coupling reactions

2019 Fall National Meeting

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