There is an ongoing need in biomedical research to rapidly identify high-quality chemical probes and drug candidates. The exchange of a CH group with a N atom in aromatic and heteroaromatic ring-containing lead compounds can have many important effects on molecular and physicochemical properties and intra- and intermolecular interactions that can meaningfully impact pharmacological profiles. This presentation will provide a perspective on leveraging the "necessary nitrogen atom" in probe and drug design, including case studies of its successful application to achieve program goals.

Leveraging the necessary nitrogen atom in chemical biology and drug discovery

2019 Fall National Meeting

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