Broflanilide shows high activity against various pests including Lepidopteran, Coleopteran, and Thysanopteran pests. The meta-diamide’s structure of broflanilide was generated by the drastic modification of a lead compound, flubendiamide, which is a ryanodine receptor modulator. However, target of broflanilide is distinct from that of ryanodine receptor modulators. Broflanilide acts as a GABA-gated chloride channel allosteric modulator and its action site was suggested to be different from that of conventional GABA-gated chloride channel antagonists (Insecticide Resistance Action Committee (IRAC) Group 2 chemicals), such as fipronil. This novel mode of action of broflanilide was recognized by IRAC and broflanilide was categorized as a new IRAC group 30, GABA-gated chloride channel alosteric modulators. Insecticidal activity of broflanilide was not different between susceptible and resistant biotypes carrying A2′S, A2′G, and A2′N mutations in each species. These results suggest that there is no cross-resistance concern in broflanilide with other insecticides. In addition, we demonstrate the low-level antagonist activities of novel meta-diamides against the human GABA type A receptor (GABA<sub>A</sub>R) α1β2γ2S, mammalian GABA<sub>A</sub>R α1β3γ2S, and the human glycine receptor (GlyR) α1β.

Discovery and mode of action of a novel insecticide, broflanilide

2019 Fall National Meeting

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