Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex diterpenoid alkaloids, indole alkaloids, and several <i>Lycopodium </i>alkaloids, will be discussed. In addition, new ways to employ CH and C–C bond cleavage in synthesis will be presented (i.e., break it to make it strategies).<br/>

Break-it-to-make-it strategies for complex molecule synthesis

2019 Fall National Meeting

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