Organotin poly(amine ethers) were rapidly synthesized in good yield employing the interfacial polycondensation system from reaction of Lamivudine and organotin dihalides. Yield increases, and molecular weight decreases as the size of the alkyl group on the tin increases. The synthesis employed commercially available reactants allowing for production in gram to ton quantities. Infrared spectroscopy showed the formation of new bands characteristic of the Sn-O- and Sn-N linkages. MALDI MS showed ion fragment clusters to ten repeat units. The polymers exhibit 100% inhibition of zika virus at concentrations of 0.025 to 0.030 microgram/mL.<br/>

Synthesis of organotin polymers from the HIV drug lamivudiine (3TC) and their ability to inhibit the Zika virus

2019 Fall National Meeting

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