Synthetic nucleic acids were synthesized from the reaction of thymidine and organotin dichlorides employing the interfacial polycondensation process.  The products were polymeric and produced in decent yield. In general chain length decreases as the size of the alkyl group on the tin increases consistent with the larger alkyl chain size interfering with chain growth.  Infrared spectroscopy results show formation of expected Sn-O bonds.  Bands associated with the R-OH are absent.  The polymers show good inhibition of the tested cell lines including those from human pancreatic, breast, lung, prostrate, and brain cancers.<br/>

Synthesis and characterization of metal-containing polymers: Synthesis of organotin-containing synthetic nucleic acids from thymidine and their ability to inhibit human pancreatic and brain cancer cell lines

2019 Fall National Meeting

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