MicroRNAs (miRNA) are an emerging class of small RNAs that play critical roles in human development and disease. These micromanagers function at the level of post-transcriptional gene regulation, and alteration of miRNA expression levels have been implicated in many human diseases. In cancer, miRNAs can have both oncogenic and tumor suppressive functions, indicating that multiple strategies will be necessary in order to target miRNAs in cancer for therapeutic development. Using our laboratory’s innovative high-throughput screening approach, catalytic Enzyme-Linked Click Chemistry Assay or cat-ELCCA,we have developed platforms for assaying RNA-small molecule and RNA-protein interactions toward our goal of developing small molecule-based modulators of miRNA biology. Our progress toward the goals of selectively targeting Dicer-mediated pre-miRNA processing and miRNA-miRNA-binding protein interactions with small molecules and natural products will be discussed.

Strategies for targeting aberrant microRNA activity in cancer

2019 Fall National Meeting

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