A series of novel conformationally locked, symmetrically substituted, chiral ligands based on a cis-vicinal diamine motif has been synthesized and evaluated for its application in asymmetric synthesis. The conformational-lock methodology is unique in the sense that it allows for symmetric derivatization of the central cis-diamine scaffold where the axial chirality of the ligand is responsible for inducing stereoselectivity. The Henry reaction was selected as a model system to tune the design of the chiral ligand in favor of product yield and enantiomeric excess.

Exploration of cis-diamine-based conformationally locked chiral ligands in asymmetric synthesis

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.