Hydrogen sulfide (H2S) is a highly toxic industrial and environmental pollutant that has recently garnered attention as an important endogenous signaling molecule, mediating many physiological processes within the human body. However, little is known about its molecular targets or metabolism, what its true concentration is in plasma and tissue, and how its concentration may be associated with various pathophysiological processes. Through molecular design, we report on the development of small molecule H2S donors as well as highly selective reaction-based probes for the real-time detection, quantification, and visualization of H2S in buffered water and living cells. We propose that these biological tools will help elucidate the primary and secondary roles of H2S as a key signaling molecule in biology.

Hydrogen sulfide: Development of selective probes and useful donors through molecular design

2019 Fall National Meeting

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