Natural products remain an enduring, but challenging, source of models and inspiration for new insect control agents.  As complex macrolide natural products, the spinosyns presented a range of challenges in exploiting their novel chemistry.  Several computational approaches including artificial intelligence and computer-aided molecular design were employed to understand and give direction to discovery efforts focused on taking advantage of this novel area of insecticidal chemistry.  Aspects of the discovery and structure activity relationships for semi-synthetic spinosyns and synthetic spinosyns mimics will be discussed.<br/>

Science at the interface: Natural products and computational approaches to understanding and exploiting their chemistry

2019 Fall National Meeting

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