Before the introduction of the highly sensitive and selective LC-MS and GC-MS instrumentation commonly used for today’s multi-residue methods, compound or class specific analytical methods were required to meet regulatory requirements.  These methods often involved cumbersome and time-consuming multi-step analyte isolation and enrichment followed by cumbersome and time-consuming multi-step cleanup.  Today’s residue methods require much less analytical rigor.  A simple extraction procedure (such as QuEChERS) followed by a simple cleanup step (such as pass-through SPE) may be suitable for accurate determination of hundreds of analytes from complex matrices.  Although simple, such extraction and cleanup methods are not fool-proof; variables in the extracts, such as water content, chlorophyll content, and lipid content, need to be considered to maximize cleanup and avoid recovery losses of individual compounds or compound classes.  In this presentation, multi-residue analysis will be discussed with emphasis on the optimization of pass-through SPE cleanup protocols.  The examples will include veterinary drug residues in meat and pesticide residues in cannabis.

Development of optimized extraction and pass-through SPE cleanup protocols for LC-MS and GC-MS multiresidue pesticide and veterinary drug analysis

2019 Fall National Meeting

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