DNA-encoded libraries have emerged as a powerful hit generation technology. Combining the power of combinatorial chemistry to enumerate large compound collections and the efficiency of affinity selection screening methods, the technology makes it possible to interrogate vast chemical space against biological targets of pharmaceutical relevance. Thus, the organic chemistry transformations that can be deployed to the synthesis of encoded libraries play a crucial role in the identification of attractive medicinal chemistry starting points: a novel synthetic method that significantly changes the scope of DNA-compatible reactions will be discussed.

DNA-encoded chemical space: Widening the scope of DNA compatible chemistry

2019 Fall National Meeting

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