Since commercial introduction of the last new herbicide mode-of-action over 3 decades ago, a novel herbicidal class of aryl pyrrolidinone anilides with a new mode-of-action has been discovered. This chemistry class interferes with de novo pyrimidine biosynthesis via inhibition of dihydroorotate dehydrogenase and has demonstrated exceptionally high levels of grass activity. From a compound with an erroneously assigned structure supplied by a third-party source, modest herbicidal activity prompted assignment of the correct structure followed by an extensive lead optimization effort that eventually culminated in the synthesis of highly active crop-selective analogs of current interest.

Discovery of tetflupyrolimet: New mode-of-action herbicide that interferes with de novo pyrimidine biosynthesis

2019 Fall National Meeting

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