Invited: Continuous biochemical monitoring requires specific and selective measurement of chemical analyte concentrations in non-invasive or minimally invasive biofluids, such as interstitial fluid, saliva, tears, and sweat. The goal in most cases is to obtain measurements that serve as surrogates for circulating analyte concentrations in blood. Although there has been a tremendous investment in technology and sensors to access and sense analytes in these biofluids, there has been a lack of understanding the biology of secretion of the fluids themselves. This is unfortunate, as many technical demonstrations, be they in-vitro or in-vivo, have little or no chance to provide meaningful blood-correlated data because of the specific choice of the analyte and/or the biofluid. Furthermore, once a proper analyte and biofluid is chosen, developing sampling and sensing technologies that are truly continuous is even more challenging.  This presentation will review recent analysis which points to interstitial fluid and sweat as the most viable sources for continuous biochemical monitoring for analytes beyond electrolytes and metabolites.  Also presented are recent technological demonstrations for sweat biosensing that show the first-ever blood-correlated continuous sweat data, with potential for a significant market application in continuous medication monitoring.<br/>

Minimimally- and non-invasive continuous biosensing: Frontiers for devices and sensors

2019 Fall National Meeting

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