The synthesis of complex (hetero)aromatics has been a central goal of organic synthesis. Densely and differentially functionalized aromatic and heteroaromatic compounds represent the core of dyes, pharmaceuticals, flavors, fragrances, agrochemicals, materials, and catalyst ligands. If a native or ubiquitous functional group, such as a carboxylic acid, could be used in (hetero)arene functionalization it would offer tremendous advantages in efficiency and site specificity. Carboxylic acids are more stable, readily available, and cheaper than boronic acids. Presented herein is a summary of recent progress from our lab. We aim to enable decarboxylative (hetero)aryl functionalization by focusing on catalyst development and minimizing off-cycle catalyst inhibition. We will describe our early efforts at salt-free decarboxylative allylation and more recent advances aimed at cross-coupling.<br/>

Catalyst development for the decarboxylative functionalization of (hetero)arenes

2019 Fall National Meeting

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