Phenoxazine is a conjugated fused heterocyclic compound commonly found in dyes, naturally-occurring antibiotics, and anti-cancer agents. A result of its conjugation of electrons, phenoxazine has excellent photophysical and electrochemical properties that make it suitable for biosensor applications. Biosensors must be capable of transmitting chemical signals through optical or electrical activities. Our group has been interested in developing biosensors for a variety of analytes. In this presentation, we describe our efforts towards a selective biosensor that is capable of detecting low to trace concentrations of hydrogen peroxide. Hydrogen peroxide plays an important biological role in medicine and the human body. Itis not only a toxic waste product in the cellular systems, but also a major player in the redox signaling pathway. The phenoxazine-based polymer was synthesized as a step growth polymerization with p-phenylenediamine as the co-monomer via a Buchwald/Hartwig reaction. The diamine co-monomer can be varied to allow for the fine-tuning of the polymer’s optoelectrical properties and stability. We will describe our synthetic approach, characterization of the small molecules and polymer, and the optoelectrical properties of the polymer.

Phenoxazine polymers for biosensor applications

2019 Fall National Meeting

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