The focus of this work is developing a method for the preparation of substituted pyridylphosphine oxides using cross-coupling strategies. Substituted pyridines are important in medicinal chemistry and in the pharmaceutical industry and are often prepared using metal mediated cross-coupling methods. We have successfully prepared a bipyridylphosphine oxide from a bromopyridylphosphine oxide and pyridine N-oxide by combining several cross-coupling strategies. The specific goals of this work are to optimize the cross-coupling methodology we have developed and to apply the methodology to the synthesis of a series of substituted bipyridylphosphine oxides. The coordination chemistry of prepared bipyridylphosphines oxides with Ni(II) and Pd(II) will be explored as well. Compounds will be characterized by using proton and phosphorus nuclear magnetic resonance (1H and 31P NMR), Mass Spectrometry (MS) and single crystal X-ray crystallography where possible.

Synthesis of substituted bipyridylphosphine oxides via palladium(II) cross-coupling: Method development and application to coordination chemistry

2019 Fall National Meeting

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