Nickel catalyzed cross-coupling reactions have emerged as powerful methods to form C(sp3)–C(sp2) and C(sp3)–C(sp3) bonds. Ni-catalyzed reductive cross-coupling reactions have proven particularly useful for the cross-coupling of secondary alkyl electrophiles, often providing chiral products as racemic mixtures. Recognizing that the ability to render these transformations enantioselective would enhance their impact, our laboratory has developed enantioselective Ni-catalyzed reductive cross-coupling reactions of an array of organic electrophiles. This seminar will discuss our recent progress in this area.

Development of Ni-catalyzed enantioselective reductive cross-coupling reactions

2019 Fall National Meeting

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