The use of Organophosphorous compounds (OPCs) is widely spread, and their use can result in nutrient pollution in soils, waterways. OPCs are also commonly used as chemical warfare agents and are generally considered dangerous and toxic. We are exploring novel methods of OPCs detoxification based on new complexes and architectures inspired by the enzyme Purple-Acid phosphatase. Our complexes include an electron rich ligand donor and a non-innocent ligand as a substitute for a second metal site. Computational methods were explored to elucidate a plausible mechanism. Tests were carried out using (4-nitrophenyl) phosphate as a substitute for OPCs, and kinetics data was plotted using UV-Vis spectroscopy. Experiments are carried out in the presence of a mild reducing agent, and different pH buffers to study their effect on the kinetics of degradation. These complexes were also tested in the presence of various substituted oximes and their kinetic behavior reported alongside mechanisms.<br/>

Exploring salen ligand type inspired from purple-acid phosphatase towards catalyzing pesticides hydrolysis with zinc complexes

2019 Fall National Meeting

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