[6]-Shogaol (6S), one of the major bioactive components in dry ginger, is attracting considerable attention because of its wide spectrum of biological activities, but its metabolic fate especially the metabolism of 6S by gut microbiota is still not fully understood. This talk will present our recent findings on the impact of gut microbiota on the metabolism and bioactivity of 6S. The microbial metabolism of 6S was examined for the first time in germ-free (GF) and specific pathogen free mice and in <i>in vitro</i> batch human fecal fermentation system. The major microbial metabolites of 6S were detected and identified by LCMS analysis and in comparison with authentic standards. We also demonstrated that the inactive glucuronidated 6S and its phase I and thiol conjugated metabolites could be rapidly de-conjugated by human gut microbiota and in mice to the active free forms in the GI track. In addition, we also observed the interindividual variability on the formation of microbial-derived metabolites of 6S by human gut microbiota.

Impact of gut microbiota on the metabolism and bioactivity of [6]-shogaol in ginger

2019 Fall National Meeting

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