We will present the results of the control and regulation of proton gradient and coupling across membrane mimics using interfacial molecular assemblies of various Coenzyme Qs (CoQ). We use electrochemical and spectroscopic measurements to quantify proton gradient and investigate proton coupling modes across membrane mimics. The chemical interface produced between immiscible phases of water and 1,2-Dichloroethane is used as a model chemical interface and a membrane mimic. Electrochemical impedance spectroscopy analysis shows that proton gradient across such interfaces is controlled by the pH of the aqueous phase. We particularly show that fat-soluble molecules known for their proton coupling action in biological systems such as coenzyme Q<sub>0-10 </sub>and quinone could change the impedance response associated with proton gradient across interfaces. We use interfacial molecular assemblies of ferrocene type redox agents and CoQs to control interfacial proton gradient. Interestingly, interfacial proton coupling varies between different CoQ type molecules, and impedance spectroscopy show signatures which are assigned to proton coupled electron transfer of these assemblies.  We will discuss our results showing proton coupling regulation across membrane mimics and mechanistic differences shown in proton coupling activity of different CoQ type molecules.<br/>

Proton couplings of coenzyme Q across membrane mimics

2019 Fall National Meeting

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