Pterostilbene, found in a wide variety of food sources, has been documented to have many health-promoting functionalities. However, the oral bioavailability of Pterostilbene is limited due to its poor solubility in aqueous environment. Encapsulation of pterostilbene in the oral delivery system become a popular means to enhance the solubility, stability, bioaccessibility and, thus, its oral bioavailability. In this work, nanoemulsiosn systems were carefully designed and optimized. To find the optimum formulation, lecithin, MCT oil, and water, were investigated using the pseudoternary phase diagram. Nanoemulsion was formed after passing 5 cycles through a high-pressure homogenizer at 500 psi. The rheological properties and particle size were measured by dynamic light scattering and viscosmeter. The storage stability of prepared formulations was determined based on its ability to maintain its particle size and loading concentration, which is analyzed using a dynamic light scattering method and HPLC, respectively. According to the experimental results, the nanoemulsion system composed of 1.5% lecithin (w/w) could produce the optimum nanoemulsion formulation that more than 20% loading of pterostilbene and could remain stable for over 1 month. The antioxidant activity was found significantly improved in chemical and cellular models. The positive effect of prepared nanoemulsion system on the bioavailability was studied and confirmed by <i>in vitro</i> lipolysis and Caco-2 monolayer model. To sum up, the nanoemulsion system could successfully enhance the solubility, stability, and bioavailability of pterostilbene. This work is by far the first few reported successful oral formulation for Pterostilbene and could serve as future reference for further development.

Development of phospholipid-based pterostilbene nanoemulsion system: Preparation, storage stability, and oral bioavailability

2019 Fall National Meeting

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