An all-solid-state potentiometric aptasensor array based on a multichannel disposable screen-printed carbon electrode (SPCE) was demonstrated for the simultaneous detection of Hg2+, Cd2+, and As3+ by open circuit potential (OCP) technology. The potential of the channel with an internal calibration DNA sequence (IC-DNA) was employed as the internal calibration potential (ICP) to subtract the background signal generated by the system, providing a built-in correction methodology. As a result, the developed aptasensor array showed high sensitivity and accuracy for detecting Hg2+, Cd2+, and As3+ without mutual interference or interference from other ions. The linear response ranged from 2.5 pM to 2.5 μM, and the detection limits for Hg2+, Cd2+, and As3+ were 2.0, 0.62, and 0.17 pM, respectively. Furthermore, compared with the obtained results from inductively coupled plasma mass spectrometry, the potentiometric aptasensor array was successfully applied for the simultaneous detection of three ions in real samples.

Internal calibration potentiometric aptasensors for simultaneous detection of Hg2+, Cd2+, and As3+ based on a screen-printed carbon electrodes array

2019 Fall National Meeting

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