Growth arrest-specific gene 6 (Gas6) is a member of the vitamin K-dependent protein family, and is believed to play a role in platelet activation and endothelium dysfunction. Previous data suggested that Gas6 is a novel platelet and vessel wall target with a potential to improve clinical outcome of atherothrombotic diseases. Herein we present our structure-based design approaches using a crystal structure of the Gas6/Axl receptor complex to identify an Axl-derived β-hairpin millamolecule. The peptide was shown to bind Gas6 with high affinity and disrupt Gas6/Axl complex formation and inhibit platelet activation.

Identification of a β-hairpin peptide that disrupts growth arrest-specific gene 6 (Gas6)/Axl receptor interaction

2019 Fall National Meeting

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