Abstract Herein, we report a safe, high yielding and scalable synthesis of diazeniumdiolates (DAZD) and the application for the synthesis of MK-8150, a novel O2-alkylated diazeniumdiolate NO donor, as a potent and significant blood-pressure lowering drug candidate in humans.

Safe and high yielding synthesis of diazeniumdiolates and the application for synthesis of MK-8150

2019 Fall National Meeting

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