The dynamic posttranslational modification of proteins by O-linked-β-N-acetylglucosamine (O-GlcNAcylation) plays many diverse roles in cellular physiology and disease. Here we will describe a quantitative, systems-level approach for studying the function, specificity, and dynamic regulation of O-GlcNAcylation. Elucidation of the signaling networks associated with the O-GlcNAc modification provides new insights into its central functions and may reveal new therapeutic approaches to enable its selective modulation.

Chemical approaches toward a quantitative, systems-level understanding of protein O-GlcNAcylation signaling networks

2019 Fall National Meeting

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