En route for highly functional biomaterials and nanodevices, amphiphilic block copolymer structures are gaining in complexity and precision in their macromolecular structure. In addition to their intrinsic self-assembly properties, they may include stimuli-responsiveness possibly in addition to relevant biological functions. By combining the self-assembly properties of block copolymers together with the richness of function-bearing peptides, protein or saccharide domains, we aim at creating functional nanosystems integrating the advantages of both materials. We developed synthetic strategies for the design of polypeptides and polysaccharide-polypeptide biohybrids with controlled placement of sugar functionality. We were interested in designing copolymers able to self-assemble into well-defined micelles and vesicles that can advantageously be loaded with drugs and present a surface with multivalent presentation of bioactive saccharides or oligosaccharides that were shown to target specific cell receptors.

Synthesis and self-assembly of biomimetic polypeptide-based copolymers towards functional nanomedicines

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.