Recent literature suggests increasing amount of resistant starch (RS) in diet may confer protective effects on chronic diseases such as obesity, CVD and diabetes. Rice is a staple food rich in starch and can be a good dietary source of RS. However, it remains unclear if RS and its amount consumed in the form of rice may have health benefit. To answer these questions, we examined the effect of rice varietal containing different levels of RS as the main carbohydrate source in a rodent diet-induced obesity model. C57BL/6J mice (n=60, male, 5 weeks old) were randomly assigned to six groups: 1) low-fat (10%) and low-RS (Titan, 0.11 wt.% RS) diet (LF-LRS); 2) high-fat (39%) and low-RS diet (HF-LRS); 3) low-fat and medium-RS (Presidio, 1.07 wt.% RS) diet (LF-MRS); 4) high-fat and medium-RS diet (HF-MRS); 5) low-fat and high-RS (Mutant, 8.61 wt.% RS) diet (LF-HRS); and 6) high-fat and high-resistant-starch diet (HF-HRS). The animals were fed the diets for 8 weeks. We found that the main fecal SCFAs (acetate, propionate and butyrate) content was significantly (p &lt; 0.0001) higher in HRS groups than other RS groups. Also, the epididymal fat mass gain induced by high-fat diet was attenuated by MRS and HRS intake. The adipose weight changes correlated (p &lt; 0.01) with changes in the leptin, adiponectin, and lipoprotein levels in plasma, as well as the triglyceride level in liver. Furthermore, the mRNA levels of the enzymes involved in triglyceride (<i>ACAT1, ACOX1, FASN, LPL</i>) and cholesterol (<i>LCAT, HMGCR, CYP51</i>) metabolism in the liver were also significantly (p &lt; 0.01) correlated with the adipose weight. These data suggest that daily intake of rice containing RS as low as 1% might attenuate fat deposit induced by high-fat diet.

Effects of rice with different amount of resistant starch on mice fed high-fat diet: Attenuation of adipose weight gain

2019 Fall National Meeting

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