Since legalization at the start of 2018, California’s legal cannabis market has been expanding rapidly, in part due to the wide array of new product types. Many of these are complex matrices that have not been fully researched prior to state level compliance testing. This is an obstacle for cannabis testing labs, where undefined matrix effects may hinder the development of highly accurate and precise testing methods. In this investigation of potency testing of cannabis-infused chocolates, various sample preps are analyzed for their accuracy and repeatability. These experiments suggest there is signal suppression of delta9-THC by the chocolate matrix itself. This presentation will discuss the scope of signal suppression on cannabinoid analytes, possible sources of suppression, and efforts to overcome this phenomenon. The field of cannabinoid analyte testing in complex matrices is still in its very early stages but is highly relevant to commercial cannabis testing.

Investigation of matrix effects in cannabis-infused chocolates

2019 Fall National Meeting

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