While a growing number of chemicals have been developed and introduced into commerce over the past several decades, there is a dearth of exposure and toxicity information available to assess potential harmful effects of these chemicals to humans or to provide information needed to regulate and screen chemicals. For this reason, high-throughput screening (HTS) assessments that incorporate both exposure and toxicity data are recommended for risk-based screening and prioritization.  Models to estimate exposure given a particular use category are reasonably well developed.  However, these models need to incorporate source estimates into various use pathways, and although this is not generally known, various approaches have been developed in recent years to estimate these values.  One approach for knowing compounds used in the home is comprehensive chemical profiles of indoor dust.   SVOCs released from their original sources are fairly persistent indoors, and thus redistributed over time and partitioned to indoor air, settled dust, and other indoor surfaces.  Advances in liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) and gas chromatography (GC)-QTOF/MS analytical workflows applying a combination of target, suspect, and non-target screening approaches has advanced this field.  We present results detecting over 250 compounds from house dust collected in California.  We utilized <i>in vitro</i> toxicology tests to identify newly detected compounds in our dust that have endocrine disrupting and neurotoxic potential.  These identified compounds should further be studied in the context of consumer products, as they are most likely entering the home from consumer product use, and serves to broaden the landscape of chemicals that should be considered. <br/> <br/>

High-throughput exposure assessment: Overview and integration on non-target dust analysis

2019 Fall National Meeting

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