Cancer has been one of the most pervasive and malignant diseases nowadays. Laser photothermal therapy (PTT), which ablates tumor cells via laser-induced hyperthermia, has been proven as an effective and non-invasive therapeutic method. Various nanomaterials have been investigated as photothermal transduction agents (PTAs); however, the following prerequisites must be fulfilled: 1. High biocompatibility and low toxicity to the local tissue environment; 2. High photothermal conversion efficiency; 3. Absorption ranges that fall in the NIR window I (650nm-900 nm); 4. High photothermal stability, allowing PTAs to maintain their structural integrity and related absorption under cycles of laser irradiation. Gold (Au) nano-materials are favored as PTAs for their well-known biocompatibility and low toxicity with the advantages of tunable NIR absorption and high photothermal conversion efficiency. However, its photothermal stability has been under questioned. Here, we developed a Au-based multifunctional chemo-photothermal PTA with improved photothermal stability and investigate its potential application in chemo-photothermal synergistic cancer treatment. A gold-platinum (Au-Pt) coaxial nanotube structure was synthesized by empolying a template-guided method (Fig. a and b). The tunability of absorption was realized by adjusting ratio between the wall thickness and diameter of the inner cavity (Fig. c). The photothermal stability results showed that the Au-Pt nanotube can maintain their shape integrity after several laser irradiation cycles as shown in Fig. d1 and d2, comparing with pure Au nanorods and Au nanocages (Fig.. e1 and e2, Fig. f1 and f2 respectively), which are popular PTAs in the field. Anticancer drug doxorubicin was loaded in the nanotube structure.The Au-Pt nanotube showed excellent synergistic photothermal-chemo therapeutic effect to cancer cells under laser irradiation (Fig. g).

Synthesis of Au-Pt coaxial nanotubes with high photothermal stability for chemo-photothermal therapy

2019 Fall National Meeting

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