This work aims to expand the scope of sulfonamide cross-electrophile coupling (XEC) reactions for cyclopropane synthesis to include various heterocycles. Additionally, the synthesis of an enantioenriched substrate is carried out in order to determine the stereochemical outcome of the XEC. Transition metal-catalyzed XEC reactions, an alternative to cross-coupling (XC) reactions, are important because they allow for facile construction of C–C bonds without the use of organometallic coupling partners. XECs of amines typically require strained or charged starting materials, but this method utilizes unstrained and uncharged alkyl amines. The cyclopropane motif is important in medicinal chemistry because the C–H bonds have increased metabolic stability in drug molecules.

Expansion of scope for nickel-catalyzed cross-electrophile couplings of sulfonamides for cyclopropane synthesis

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.