The human body is an ecosystem that hosts a variety of microorganisms and a majority of those are colonized in human gastrointestinal tract (GIT). Some of these microbes were considered as probiotics such as genus bifidobacterium and lactobacillus, showing beneficial effects on human GIT disorders. We isolated a strain of bacteria from feces of a healthy male adult that was identified as <i>Bifidobacterium pseudocatenulatum UMA14 </i>based on the gene sequencing. To determine the potential health effects, the bacterial secretion of the strain was subjected to cell culture models to establish the potential anti-inflammatory and anti-cancer effects. The results showed that adding the bacterial secretion to lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages lead to a significant inhibition on the nitric oxide production and NF-kB signaling. Moreover, the bacterial secretion inhibited the growth of human colorectal carcinoma (HCT116) cells, and the inhibition was associated with increased apoptosis. Overall, our results demonstrated the anti-inflammatory and anti-cancer effects of <i>Bifidobacterium pseudocatenulatum UMA14 </i>isolated from human gut, and future studies are warrant to further elucidate the in vivo efficacy of the bacterial strain.

Identification of a human gut bacterial strain with anti-inflammatory and anti-cancer properties

2019 Fall National Meeting

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