Compounds containing cyclopropanes are known to be naturally occurring and possess medicinal properties. Developing new methods of these strained three-membered rings will give access to novel synthetic pathways for medicinally active compounds. This work utilizes sulfonamides and alkyl halides in a nickel-catalyzed cross-electrophile coupling reaction to synthesize cyclopropanes. Traditional cross-coupling reactions utilize an organometallic nucleophile and an electrophile as coupling partners, but the cross-electrophile coupling reaction instead requires two different electrophiles. This is an important method to explore as electrophiles have greater commercial availability compared to organometallic nucleophiles.<br/>

Synthesis of cyclopropanes using nickel-catalyzed cross-electrophile coupling reactions

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.