Here we describe a fluorescence-quenched analogue of the mycobacterial glycolipid trehalose dimycolate (TDM), which is a major component of the mycobacterial outer membrane (“mycomembrane”). The fluorogenic probe, called FRET-TDM, is activated by the mycomembrane- remodeling enzyme trehalose dimycolate hydrolase (TDMH) and other mycobacterial enzymes. It should be valuable for studying TDMH, mycomembrane remodeling processes, and may be a useful approach to developing mycobacteria-specific detection reagents, which are needed to improve tuberculosis diagnosis.

FRET-based fluorogenic trehalose dimycolate analogue for probing mycomembrane-remodeling enzymes of mycobacteria

2019 Fall National Meeting

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