The chemoselective functionalization of dihaloaromatics plays a vital role in the synthesis of medicinally relevant building blocks. The site selectivity of C–X (X = halogen) activation is determined by factors such as the position of the halogen on the ring, the solvent, the nature of the nucleophile, and catalyst being employed in the transformation. Presented is an illustration of chemoselective functionalization using Fe-, Cr-, and organo-catalysis to form sp3-sp2, sp2-sp2, and sp-sp2 bonds.

Highly chemoselective functionalization of dihaloaromatics

2019 Fall National Meeting

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