Recognition of DNA and RNA is significant because of the number of roles these molecules play in biology. DNA and RNA polymers and oligomers can be sequence-specifically recognized by other oligonucleotides. Small molecules on the other hand are much better at shape and sequence recognition of shorter sequences. Recognition of secondary structures in RNA can also be achieved by small molecules. Can long oligonucleotides and small molecule approaches be mutually beneficial and synergistic? In this presentation, I will share our recent results in the exploration of such a paradigm.<br/>Carbohydrate (ribose) composition is approximately a third of the molecular mass in DNA and RNA, yet the ACS division of carbohydrate chemistry has carried most of the weight and championed the cause of the nucleic acid community to provide a long standing forum in its programming. I have had the privilege to be a part of this decades old tradition and look forward to reflecting upon this experience at such an opportune time in the history of the division.

Recognition of DNA and RNA with small, large and intermediate size molecules

2019 Fall National Meeting

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