Asymmetric catalysis is a powerful and sustainable method for preparing chiral compounds. Most catalysts are only tested in benchmark substrates, eluding challenging ones that would yield to more appealing compounds. Here I present our recent finding in the design of improved catalyst libraries for the elusive and challenging asymmetric hydrogenation (AH) of cyclic b-enamides and tetrasubstituted olefins.<sup> </sup>These reactions led to the formation of important chiral synthons, such as aminotetraline and aminochromanone derivatives, which can be found in numerous therapeutic agents and biologically active natural products (e.g. rotigotine, alnespirone,...).<sup> </sup>Despite this, they are underdeveloped compared to the AH of the most studied and solved a-enamides and trisubstituted olefins. Finally, I would also show the design of improved catalysts for the preparation chiral (poly)carbo- and heterocyclic compounds, with multiple stereocenters, by using straighthforward sequences of allylic substitution an either 1,6-enyne cyclization, or ring-closing metathesis or Pauson-Khand reactions.

Improved generations of catalysts for asymmetric synthesis and stereoselective reactions

2019 Fall National Meeting

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