Bacteria are essential to maintaining host health and contributing to host illness. While growth and virulence are influenced by local parameters such as nutrient availability, our understanding of how a host and bacterium communicate to cause different outcomes is deficient. Accordingly, deciphering bacteria-host communication is necessary for understanding the evolution of chemical signal development and disrupting specific aspects of the information exchange. This seminar will focus on defining how human milk oligosaccharides (HMOs) maintain microbiome homeostasis over dysbiosis. We will also discuss the minimal pharmacophoric units responsible for antimicrobial activity and HMO potentiation of intracellular-targeting antibiotics.<br/>

Human milk oligosaccharides: Guiding temporal development of the gut flora

2019 Fall National Meeting

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