A minority of cells with unique phenotypic or genotypic characteristics can drive disease progression and response to therapeutic agents. Therefore, single-cell analysis is critical to the accurate characterization of disease states. A major challenge for the development of next-generation devices for the evaluation of individual cells is the integration of all steps of analysis into a single platform. Such integration would greatly reduce the time and cost of diagnosis while increasing accuracy. Major challenges to the realization of this goal include a need for high volumetric throughput, selectivity for the cells of interest, and parallel and sensitive analysis. We discuss methods that leverage electrochemical and electrokinetic processes at arrays of bipolar electrodes (BPEs) to address each of these challenges. Specifically, we will discuss selective capture of cells by dielectrophoresis (DEP) at BPEs and the integration of electrochemical sensing to achieve sensitive and rapid analysis.<br/>

Integration of dielectrophoretic selective single-cell capture at a wireless electrode array with on-chip analysis

2019 Fall National Meeting

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