Salicylic acid (SA) is known for its anti-inflammatory properties; it is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation by inhibiting the cyclooxygenase (COX) activity. The issue of short half-life of SA <i>in vivo</i> can be addressed by controlled release of SA through a degradable polymer matrix. The polymerization of SA with linker molecules such as adipic acid yielded biodegradable, biocompatible salicylic acid- based poly(anhydride-esters) (SAPAE). The SAPAEs have been successfully processed into membranes by electrospinning and utilized as bone grafts in bone regeneration. The application of SAPAE membranes for treating bone defects in diabetic rats show promising results: -after 12 weeks, the SAPAE/bone grafted diabetic rats had 43% more bone fill than the control, with no statistical difference in normoglycemic rats. Here, we provide an overview of synthesis of SAPAEs, strategies to modulate the hydrolytic degradation rate of polymers to optimize sustained release of SA, structure- property relationships, and updates on bone regeneration results.

Salicylic acid based biodegradable, biocompatible poly(anhydride esters) for bone regeneration applications

2019 Fall National Meeting

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