Carbohydrates and glycoconjugates play important roles in biology. Obtaining these structures in pure forms is critical to elucidate their functions and explore their potential therapeutic applications. We have developed highly efficient glycosyltransferase-based one-pot multienzyme (OPME) systems for synthesizing various carbohydrates from suitable glycosyltransferase acceptors and simple monosaccharides as donor precursors. These OPME systems have been used in synthesizing a library of oligosaccharides and derivatives. Their applications in structure-function relationship studies of carbohydrate-active enzymes will be presented.

One-pot multienzyme (OPME)-synthesized carbohydrate probes for structure-function relationship studies of carbohydrate-active enzymes

2019 Fall National Meeting

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