In this study, a novel metal-organic framework (MOF) delivery system for a food bioactive was developed. A series of molecular simulations tools, reported in recent years, have been applied to predict and optimize the delivery system. First, Zr-based MOF UiO-66, was synthesized with Zirconium (IV) chloride and benzene-1,4-dicarboxylic acid. Then, curcumin was encapsulated in it. Both spectroscopy and thermogravimetric analysis showed that the system achieved a high loading capacity of 3.45% w/w. The crystal structure, porosity, morphology of this curcumin delivery system was characterized using X-ray diffraction (XRD), physisorption analyzer, scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometer (EDS). In vitro test showed control release of curcumin after digestion in the simulated intestinal fluids (SIF). Around sixty percent of curcumin was released after 180 min of digestion. This research demonstrated that low toxicity and stable MOFs might have potential in constructing efficient delivery systems.<br/>

Computer-assisted design for stable porous metal-organic framework (MOF) as a carrier for curcumin delivery

2019 Fall National Meeting

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